A very large
anaconda is captured from the Amazon River basin and is being kept in a scientific lab. Certain drugs along with a serum was added to it so as to test why such a serum only has its effect on snakes. Murdoch, a well-known industrialist is paying for this research. One day the anaconda escapes from the lab and kills several scientists and assistants. A team of animal hunters led by Hammett, a well-known snake catcher, along with Dr. Haze from the lab lead their way to the forest to find this anaconda which has become very dangerous due to the drugs and serum. After sometime, Dr. Haze tells the hunters that this anaconda is pregnant. All the hunters in the team are killed except for Hammett and Dr. Haze. Haze comes to realize that Hammet works for Murdoch and wants the anaconda for money. Inside an old office, the anaconda gives birth to many babies. Haze, knowing about Hammett, leaves him in the building with all the snakes and a bomb which soon explodes. Haze leaves with a hope that she killed all the snakes. But one snake survives and is taken to Murdoch by one of his men. The story of this snake will be continued in
Anacondas: Trail of Blood.
